TBP-bound mismatched vs Watson-Crick DNA
GCB News

Transcription Factors May Inadvertently Lock in DNA Mistakes

Binding to mismatched DNA takes less energy; may explain how regulatory mutations get locked in

Center News

 picture for GAN cells (red: vimentin; blue: DAPI; green: tubulin) with big red (vimentin) aggregates (dots)
June 25, 2019

Sweet Adaptation

Investigating the effects of glucose on adaptor proteins to treat Giant Axonal Neuropathy and other diseases
Ashley Chi/David Hsu Graphic
June 17, 2019

Defending Against Kidney Cell Carcinomas

Chi and Hsu found that depriving tumors of cysteine, a non-essential amino acid that becomes essential only to tumor cells once they have been malignantly transformed, has been shown to shrink tumor cells.
June 11, 2019

GCB Receives Grant To Create New International Training Program

The Center for Genomic and Computational Biology (GCB) received a grant from the National Science Foundation (NSF) to create an International Research Experiences for Students (IRES) program called “Dissecting the Regulatory Genome Duke-Berlin Training Program.”