A diagram of the species of bacteria from an individual patient that are more likely to be found with tumor samples (blue) or normal tissue samples (yellow). The layout of the diagram shows the bacterial family tree, with node sizes proportional to the number of times a given bacterial group is observed. This specific diagram “rediscovers” that Fusobacterium species are strongly enriched in colorectal cancer and offers the new insight that Campylobacter species are also associated with the disease.
GCB News

The Cancer Microbiome Reveals Which Bacteria Live in Tumors

Researchers clean up data to identify the bugs better

By Ken Kingery

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Figure Caption: CRISPR-based activation of gene networks implicated in human stem cells becoming neuronal cells led to the generation of cells with neuronal shapes and markers (left) and enhanced function and electrophysiological properties, including producing more action potentials more frequently (right).
GCB News

It’s time to grow up

Stem cells have the potential to turn into any cell type, which makes them an incredibly powerful tool for disease modeling and...

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picture for GAN cells (red: vimentin; blue: DAPI; green: tubulin) with big red (vimentin) aggregates (dots)
June 25, 2019

Sweet Adaptation

Investigating the effects of glucose on adaptor proteins to treat Giant Axonal Neuropathy and other diseases
Ashley Chi/David Hsu Graphic
June 17, 2019

Defending Against Kidney Cell Carcinomas

Chi and Hsu found that depriving tumors of cysteine, a non-essential amino acid that becomes essential only to tumor cells once they have been malignantly transformed, has been shown to shrink tumor cells.
June 11, 2019

GCB Receives Grant To Create New International Training Program

The Center for Genomic and Computational Biology (GCB) received a grant from the National Science Foundation (NSF) to create an International Research Experiences for Students (IRES) program called “Dissecting the Regulatory Genome Duke-Berlin Training Program.”