Research Roundup: December 2019

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Research Roundup: December 2019

Here are summaries of a selection of the papers published by GCB faculty in December 2019

New Methods and Systems

Sayan Mukherjee was part of a team that developed a deep learning algorithm that can better estimate the progression and predict future patterns of visual field loss in glaucoma. Read more

Xiling Shen and team developed a system that allows for real-time observations of individual cells in the colon of a living mouse. They expect the procedure to allow new investigations into the digestive system’s microbiome as well as the causes of diseases such as inflammatory bowel disease and colon cancer and their treatments. Read more

Ashley Chi was part of a team that created a new way to examine the biophysical response of red blood cells using quantitative phase imagine. Read more

Bruce Donald and team created a new algorithm that tightens bounds on distinct regions of protein conformation space. Read more

Microbiome

John Rawls and team discovered that a high-fat meal can silence communication between the intestine and the rest of the body. While using zebrafish to examine cells that normally tell the brain and the rest of the body what’s going on inside the gut after a meal, they discovered that a high-fat meal completely shuts down that communication for a few hours. Read more

John Rawls was part of a team that describes how microbiome science is entering a new phase in its evolution, as the field is recognized as central to the life sciences and relevant to many other disciplines and industrial applications. Read more

Stages of Development

Ashley Chi, David Corcoran and teams combined single-cell RNA sequencing on a microfluidic platform and fluorescence imaging to delineate the transcriptional variations among individual parasites during late asexual and sexual stages. Read more

Greg Wray was part of a team that sequenced and analyzed RNA populations in mice and chicks during early stages of embryonic telencephalon to understand the conserved and lineage-specific developmental differences. Read more

Pathogens

Lingchong You and team describe a new phenomenon for Pseudomonas aeruginosa, an opportunistic pathogen that often infects open wounds or patients with cystic fibrosis. This discovery sheds new insights into the physiological functions of phenazines and has implications for designing effective antibiotic treatment protocols. Read more

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