Research Roundup: February 2019

stack of books
GCB News

Research Roundup: February 2019

Here are summaries of a selection of the papers published by GCB faculty in February 2019:

Disease

Doug Marchuk was part of a team that conducted a study to determine important genes, functions and networks contributing to the pathobiology of cerebral cavernous malformations from transcriptomic analysis. Read more

Marchuk was also part of a team that investigated a more aggressive treatment for cerebral cavernous malformations (CCM) in murine models using with fasudil, simvastatin, and higher dose atorvastatin. Their results support the exploration of proof of concept effect of high-dose atorvastatine on human CCM disease for potential therapeutic treatment. Read more

Charlie Gersbach and team has shown that a single systemic treatment using CRISPR genome editing technology can safely and stably correct a genetic disease -- Duchenne muscular dystrophy (DMD) -- for more than a year in mice, despite observed immune responses and alternative gene editing outcomes. Read more

Biomarkers

Using both the Dunedin Longitudinal Study and the Environmental Risk Study, Avshalom Caspi and Terrie Moffit worked with a team to construct a polyepigenetic DNA methylation score that indexes smoking behavior. This index can be used for various purposes in population health research. Read more

Related News

Svati Shah headshot

Svati Shah Named Director of Duke Precision Genomics Collaboratory

Svati Shah, M.D., MHS, has been appointed director of the Duke Precision Genomics Collaboratory and associate dean of genomics.

view

GCB Receives Grant To Create New International Training Program

The Center for Genomic and Computational Biology (GCB) received a grant from the National Science Foundation (NSF) to create an International Research Experiences for Students (IRES) program called “Dissecting the Regulatory Genome Duke-Berlin Training Program.”
view
Stack of Books

Research Roundup: May 2019

Here are summaries of a selection of the papers published by GCB faculty in May 2019:

view