Research Roundup: January 2019

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GCB News

Research Roundup: January 2019

Here are summaries of a selection of the papers published by GCB faculty in January 2019

Mental Health

Using the Environmental Risk (E-Risk) Longitudinal Twin Study, a cohort of 2.232 twins born in the U.K between 1994-1995, Avshalom Caspi, Terrie Moffitt and team investigated antecedents, clinical features, and life characteristics distinguishing dual-harming adolescents from those who self-harm only. Read more

Terrie Moffitt, Avshalom Caspi and team examined whether childhood lead exposure is associated with greater psychopathology across the life course and difficult adult personality traits using the Dunedin Multidisciplinary Health and development Study. Read more

New Frameworks/Methods

Lingchong You, Sayan Mukherjee and team developed a framework to predict and interpret mutualistic biological systems. Their strategy can pave the way for establishing and implementing other simple rules for biological systems. Read more

Andrew Allen and team improved existing methods for pathogenic variant localization and developed a statistical intolerance framework that is able to jointly model genome-wide, genic, and sub-regional effects. Read more

Viruses/Bacteria

Xiling Shen and team investigated how hepatocytes contain Hepatitis B virus (HBV) replication and promote their own survival by orchestrating a translational defense mechanism. Read more

Amy Schmid collaborated with a team to comprehensively evaluated the effects of several different weak organic acids on growth of the opportunistic pathogen Pseudomonas aeruginosa. Read more

Genetics/Genomics

Andrew Allen and team utilized the orthogonal decomposition of genotype scores in the frailty model, and derived the efficient score statistics of the within-family component parameter to construct Family-based Burden (Kernel) Association tests for rare variants with Censored traits, called as FamBAC and FamKAC. Read more

Charlie Gerbach was part of a team that quantified the bursting dynamics of Fos and Npas4 in neurons. Read more

Reviews

In this review, Lingchong You and team summarize recent work on synthetic systems that generate spatial patterns, review the tools for building synthetic patterns, and discuss future directions of studying pattern formation with synthetic biology. Read more

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