Nov 25
Christina Williams
VA Cooperative Studies Program Epidemiology Center, Durham VA Healthcare System, Deputy Director

CBB Seminar Series

  • November 25, 2019 1:00pm to 5:00pm

    Metabolomics for Clinical and Basic Research

    Location: 2240 CIEMASRegistration Deadline: Nov. 18Metabolomics has emerged as a powerful approach for characterization of molecular systems and also development of biomarkers for disease progression or diagnosis. Broadly, metabolomics is the characterization of small molecules by mass spectrometry and can include both "unbiased" or non-targeted techniques, as well as "targeted" methods.   The measurement of metabolites by mass spectrometry is also directly translatable to the clinic; many common assays such as amino acids, acylcarnitines, vitamin D epimers, steroid hormones, and drugs of abuse are all clinical mass spec assays.  Whether developing a novel assay or using a validated metabolite assay, the most important aspect for a successful metabolomics study is deciding which technique to use and understanding the data each approach will likely be able to provide. In this course, we will discuss sample types which are amenable to metabolomics, and utilize case studies to discuss the critical differences in targeted and non-targeted metabolomics and an investigator might choose one over another.  We will use example datasets to demonstrate techniques for analysis of high dimensional metabolomic data.  We will also cover the methods needed for accurate quantification, how to enable longitudinal translation of metabolomics assays, and how a targeted mass spec assay may differ in utilization from a clinical ELISA.Cost: FreeMore info and registration

  • December 6, 2019 9:00am to 10:30am

    Introduction to Biobanking

    Location: 2240 CIEMASRegistration Deadline: Dec. 2This seminar will offer an introductory overview of key considerations and best practices in establishing and maintaining clinical biospecimen collections for genomic and precision medicine research. Topics covered will include:  basic concepts in biobank and cohort research; role of standardization, harmonization, and quality control; maintaining unique sample identification and robust chain-of-custody tracking; need for secure information and inventory management systems for samples and data; important considerations in repository design; and an overview of biobanking resources at Duke and beyond.Cost: FreeMore info and registration

  • December 9, 2019 11:30am to 12:30pm

    CBB Seminar: Design principles of cellular differentiation control: lessons from Bacillus subtilis

    Location: 4233 FrenchThe computational biology seminar is a weekly series of seminars on topics in computational biology. This week, join us as Oleg Igoshin from Rice University Department of Bioengineering gives a presentation entitled, "Design principles of cellular differentiation control: lessons from Bacillus subtilis."Host: Lingchong You

  • December 10, 2019 12:30pm to 1:30pm

    UPGG Seminar Series

    Host: Ryan Baugh

  • December 18, 2019 9:00am to December 19, 2019 5:00pm

    Data Carpentry for Genomics

    Location: Bostock Library, EDGE Workshop RoomData Carpentry develops and teaches workshops on the fundamental data skills needed to conduct research. Its target audience is researchers who have little to no prior computational experience, and its lessons are domain specific, building on learners' existing knowledge to enable them to quickly apply skills learned to their own research. Participants will be encouraged to help one another and to apply what they have learned to their own research problems.RCR credits are available for faculty and staff.More informationRegistration

  • January 15, 2020 1:00pm to 6:00pm

    Identification of noncoding pathogenic variants for rare disease: An interdisciplinary colloquium

    Location: University Club, 3100 Tower Blvd, Durham, NCCo-hosted by Duke GCB. GCB faculty members Tim Reddy, Andrew Allen and Greg Crawford will be featured speakers at this event.Join us at the 2nd Annual Identification of noncoding pathogenic variants for rare disease Colloquium to explore the fundamental questions surrounding rare diseases and gene regulation.This colloquium series is designed to build community and unite expertise around the genetic causes of rare mendelian disease, specifically identifying pathogenic noncoding mutations in rare diseases.This session will explore fundamental questions, current approaches, and developing methods at the intersection of clinical, experimental, and quantitative perspectives. The first half of the day will include an overview of genomics at Duke and current efforts in the noncoding space. The second half will include phenotype-specific presentations in the context of identifying regulatory causes. The day will end with a facilitated discussion to explore critical questions on the long-term goals and outcomes of these scientific questions.The cross discipline agenda aims to optimize opportunities for scientific achievement in the area of rare diseases and gene regulation.Full AgendaRegister

  • January 16, 2020 12:00pm to 1:00pm

    Resilience in Aging

    Location: Duke University Hospital Lectural Hall room 2002Department of Psychiatry & Behavioral Sciences’ 2019-2020 Grand Rounds Ewald Busse Memorial Lecture.Speaker Host: John Beyer, M.D.Please contact John Beyer or Lynn Labuda if you are interested in meeting with the speaker.

  • January 21, 2020 4:00pm to January 25, 2020 11:00pm

    Beyond a Million Genomes: From Discovery to Precision Health

    Location: Beaver Run Resort, Breckenridge, Colorado, USAHigh-throughput genotyping and DNA sequencing technologies have enabled a deeper understanding of the genetic basis of human health and disease. These genomic insights offer huge opportunities for the development and implementation of more targeted therapies and preventive strategies, known as precision health. This meeting will focus on rapidly advancing and emerging areas of precision health, emphasizing the path from discovery to clinical implementation. The Symposium will begin with the state of our current knowledge of the allelic architecture of human disease and how this knowledge is being translated into clinical practice. Sessions will cover discovery and translational advances in Mendelian diseases, rare human gene knock-outs and common multifactorial diseases. The challenges and opportunities of big data analysis and integration, such as examining large genomic databases linked to electronic health record data, will be addressed. Other topics will include translating cancer genomics to clinical advances, workshops on clinical interpretation of germline and somatic mutations, pharmacogenomics, and the role of human genomics for novel therapeutic development. Finally, we will look beyond human sequence variation to consider the role of epigenomics, the microbiome, and environment and lifestyle in precision health. The unifying theme of this Symposium is to bridge basic human genomic discovery to clinical implementation, with the goal of attracting and engaging a broad multidisciplinary audience.More infoRegister

  • February 27, 2020 12:00pm to 1:00pm

    Early Emergence of Depression: Understanding Risk Factors and Treatment

    Location: Duke University Hospital Lectural Hall Room 2002Department of Psychiatry & Behavioral Sciences’ 2019-2020 Grand Rounds Lecture.Speaker host: Alison Adcock, M.D., Ph.D.Please contact Alison Adcock or Lynn Labuda if you are interested in meeting with the speaker

  • March 26, 2020 12:00pm to 1:00pm

    The Reciprocal Relationship of Neurocognitive and Neuropsychiatric Symptoms in Late Life Mental Health Disorders

    Location: Duke University Hospital Lectural Hall Room 2002Department of Psychiatry & Behavioral Sciences’ 2019-2020 Grand Rounds Lecture.Speaker Host: Chris Marx, M.D.Please contact Chris Marx or Lynn Labuda if you are interested in meeting with the speaker.

  • April 2, 2020 12:00pm to 1:00pm

    Mechanisms of Gene X Environment Interactions in Psychiatry - From Molecules to Behavior

    Location: Duke University Hospital Lectural Hall Room 2002Department of Psychiatry & Behavioral Sciences’ 2019-2020 Grand Rounds Lecture.Speaker Host: Doug Williamson, Ph.D.Please contact Doug Williamson or Lynn Labuda if you are interested in meeting with the speaker.

  • May 12, 2020 8:00am to May 15, 2020 5:00pm

    IRTG Retreat

    Location: Berlin