Hashim Al-Hashimi, PhD

Hashim Al-Hashimi, PhD

Professor of Biochemistry

Research in the Al-Hashimi lab ranges from the theoretical design and implementation of new NMR experiments for probing the physicochemical properties of biomolecules, to structure, dynamics, and functional characterization of processes that underlie gene expression and regulation and HIV replication, to high throughput screening and computational docking to identify small molecule that bind and modulate the activity of biomolecules. We are particularly interested in RNA and DNA and the proteins and small molecules that bind to them.

Dr. Hashim M. Al-Hashimi is James B. Duke Professor of Biochemistry and Chemistry at Duke University School of Medicine and is the Director of the Duke Center for RNA Biology. He received his doctorate in Biophysical Chemistry from Yale University in 2000 for research on the development of residual dipolar coupling NMR methods to study the structure and dynamics of proteins. He is the recipient of several awards and honors, including the Founder’s Medal in NMR spectrscopy, the Vilcek Prize For Creative Promise in Biomedical Science, and the Agilent Thought Leader Award. Dr. Al-Hashimi’s work on molecular visualization and nucleic acid dynamics was also recognized by Popular Science Magazine, which listed him among the ‘Brilliant 10’ scientists and engineers in USA (2011). In 2009, he co-founded Nymiurm Inc, which is using the methods developed in the Al-Hashimi lab to increase the pace of RNA structure characterization and RNA-targeted drug discovery.

Research Interests

Structural Biology of HIV-1
RNA Dynamics
RNA Drug Design
DNA Dynamics
Methods development

Recent Publications

Kelly, ML; Chu, C-C; Shi, H; Ganser, LR; Bogerd, HP; Huynh, K; Hou, Y; Cullen, BR; Al-Hashimi, HM
January 1, 2021
Abou Assi, H; Rangadurai, AK; Shi, H; Liu, B; Clay, MC; Erharter, K; Kreutz, C; Holley, CL; Al-Hashimi, HM
December 2, 2020
Xu, Y; Manghrani, A; Liu, B; Shi, H; Pham, U; Liu, A; Al-Hashimi, HM
November 20, 2020
Shi, H; Rangadurai, A; Abou Assi, H; Roy, R; Case, DA; Herschlag, D; Yesselman, JD; Al-Hashimi, HM
November 2, 2020
Afek, A; Shi, H; Rangadurai, A; Sahay, H; Senitzki, A; Xhani, S; Fang, M; Salinas, R; Mielko, Z; Pufall, MA; Poon, GMK; Haran, TE; Schumacher, MA; Al-Hashimi, HM; Gordân, R
November 1, 2020