Research Roundup: February 2021

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Research Roundup: February 2021

Here are summaries of a selection of the papers published by GCB faculty in February 2021:

COVID-19

Xiling Shen was part of a team that performed RNA sequencing on whole blood samples from 46 individuals with PCR-positive, symptomatic SARS-CoV-2 infection and compared them directly to subjects with other respiratory infections and healthy controls. Read more

FERROPTOSIS

Ferroptosis is a form of regulated cell death. Previously, only iron was the known metal to regulate ferroptosis. Ashley Chi and team, though, discovered that the addition of zinc can also cause ferroptosis. Read more

Ashley Chi and team discovered that recurrent breast tumor cells, when compared to primary tumor cells, are highly sensitive to ferroptosis. Read more

GWAS

Tom Mitchell-Olds and team quantified percentage anaerobic germination in 2,700 wet-season and 1,500 dry-season sequenced rice genotypes and performed GWAS using 693,502 single nucleotide polymorphisms. Read more

NEW METHODS AND MODELS

Raluca Gordan collaborated with Duke-NUS to develop the "Signature-QBiC" model that integrates signature profiles of mutational processes with the QBiC estimates of changes in binding affinity to investigate the effect of mutational signatures on the binding of 582 human transcription factors. Read more

John Rawls part of team that showed an acoustofluidic rotational tweezing platform that enables contactless, high-speed, 3D multispectral imaging and digital reconstruction of zebrafish larvae for quantitative phenotypic analysis. Read more

Obesity and the microbiome

John Rawls and team analyzed clinical, metabolomic and microbiome samples from adolescents with obesity as they undergo lifestyle modifications. Read more

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