Research Roundup: June - July 2021

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GCB News

Research Roundup: June - July 2021

Here are summaries of a sampling of the papers published by GCB faculty in June and July 2021:

New Methods and Models

Cell-mediated living fabrication holds promise for generating materials with versatile, programmable functions. Lingchong You, Xiling Shen and team engineered living material from semi-interpenetrating polymer networks. Their work lays the foundation for programming functional living materials for diverse applications. Read more 

Tim Reddy, Bill Majoros, Greg Crawford and Andrew Allen were part of a team working to create better tools to identify a precise genetic diagnosis in individuals who have exhausted the conventional testing approaches. Read more

Alex Hartemink, David Macalpine and team developed RoboCOP, a multivariate state space model that integrates chromatin accessibility data with nucleotide sequence to jointly compute genome-wide probabilistic scores of nucleosome and TF occupancy, for hundreds of different factors. Read more

Microbiome

Jenny tung was part of a team that leveraged over 16,000 gut microbiome profiles collected over 14 years from 585 wild baboons to reveal that the host genetic effects on the gut microbiome are nearly universal. Read more

Lawrence David, Sayan Mukherjee and team developed a paired modeling and experimental approach to characterize and mitigate PCR bias from non-primer-mismatch sources in microbiota surveys. Read more

John Rawls and team used single-cell RNA sequencing to provide a cellular atlas of the zebrafish intestinal epithelium and uncover roles for farnesoid X receptor in transcriptional and differentiation programs in ileal and other cell types. Read more 

Cancer

Ashley Chi and team used RNA-Seq to analyze the transcriptome response to MESH1 knockdown in human cancer cells. Read more

Aging

Using the Dunedin Longitudinal Study, Avshalom Caspi, Terry Moffitt and team studied biomarkers to test whether people who experienced more stressful live events during adulthood would show elevated systemic inflammation when followed up at ag 45. Read more

Ecology

Tom Mitchell-Olds and team investigated mechanisms that may maintain variation in a focal polymorphism – leaf chemical profiles of a perennial wildflower – explicitly interrogating multiple ecological and genetic processes including spatial variation in selection, antagonistic pleiotropy and frequency-dependent selection. Read more 

 

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