Research Roundup: February 2020

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GCB News

Research Roundup: February 2020

Here are summaries of a selection of the papers published by GCB faculty in February 2020:

New Methods

Ashley Chi collaborated with a team to establish a key mechanism by which 27-hydroxycholesterol inhibits prostate cancer. This is the first study to provide a mechanistic basis for the anti-tumor activity of 27-hydroxycholesterol in prostate cancer. Read more

David Hsu was part of a group identified a new mechanism that represents a tumor-intrinsic adaptive resistance mechanism to anti-PD-1 checkpoint inhibitor immunotherapy, which is a promising target for future translational research. Read more

Gene‐set analyses are used to assess whether there is any evidence of association with disease among a set of biologically related genes Andrew Allen and team developed a novel higher criticism (HC) statistic for signal detection that incorporates prior information concerning the relative importance of genes within a gene‐set into the analysis. Read more


Charlie Gersbach was part of a collaboration that identified a unique human-induced pluripotent stem cell-derived subpopulation of chondroprogenitors that exhibit high chondrogenic potential, providing a purified cell source for cartilage tissue engineering or disease modeling studies. Read more

Sandeep Dave was part of a team that provided among the first molecular characterizations of diffuse large B-cell lymphoma (DLBCL) from sub-Saharan Africa, demonstrated marked gene expression differences by HIV status, and identified genomic and immunophenotypic characteristics that can inform future basic and clinical investigations. Read more

Mental Health

Using data from the Dunedin Longitudinal study, Avshalom Caspi and Terrie Moffitt were part of a team that investigated whether life-course-persistent antisocial behavior is associated with neurocognitive abnormalities by testing the hypothesis that it is also associated with brain structure abnormalities. Read more


Amy Schmid and team reviewed the biogeography, currently known limits of life, and molecular adaptations to extremes. Users can view an online interactive map for additional detail on biogeography, environmental microbiology, and exemplary species. Read more

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Congratulations MEDx Colloquia award recipients: Charlie Gersbach, Edward Smith, Simon Gregor, Xiling Shen, Jessilyn Dunn, Raluca Gordon

GCB Faculty among MEDx Colloquia Award Recipients

Duke GCB faculty are represented in each of the three 2020 MEDxColloquia Awards. These colloquia are designed to bring together phys