The Gordan lab studies the mechanisms by which transcription factors are recruited to their specific DNA sites, both in vitro and in vivo, and how this recruitment is affected by changes in the DNA or protein sequence. We use protein binding microarray assays and computational approaches that combine different types of information relevant for DNA binding and transcriptional regulation.
Raluca Gordan is an assistant professor appointed jointly in the Center for Genomic and Computational Biology and the Department of Biostatistics and Bioinformatics, with secondary appointments in the Department of Computer Science and Department of Molecular Genetics and Microbiology. She received her PhD in Computer Science in 2009 from Duke University, where she worked on DNA motif discovery algorithms under the supervision of Prof. Alex Hartemink. Dr. Gordan conducted postdoctoral research with Prof. Martha Bulyk at Brigham & Women's Hospital and Harvard Medical School (Boston, MA), studying the DNA binding specificity of transcription factors using protein binding microarrays. She joined the faculty at Duke in September 2011.