Events

  • March 5, 2019 12:00pm to 1:00pm

    How development scaffolds internal hippocampal dynamics

    Location: Bryan Research 103The Cossart lab studies the circuit basis of hippocampal assemblies from development into adulthood and across different states of the normal and pathological brain. To describe the circuit basis of cortical dynamics, they have developed a unique multidisciplinary approach that combines in vitro and in vivo calcium imaging, electrophysiology, holographic photo-stimulation, neuroanatomy, data mining, mouse genetics and behavior. In this talk Dr. Cossart will present both published and unpublished data from her lab indicating that internal hippocampal dynamics are remarkably structured and organized and that this functional organization is set very early during development.

  • March 9, 2019 5:00pm

    Student-Faculty Show: “Duke’s Avengers: Civil Ward”

    Location: Duke’s Page AuditoriumOn March 9th, 2019, the Duke University School of Medicine will be holding its annual Student-Faculty Show entitled  “Duke’s Avengers: Civil Ward.” The entirely student-run show offers a comedic view of the medical student experience at Duke.We invite you and your faculty to attend the show, which will start at 5:00pm in Duke’s Page Auditorium. The proceeds from our annual event benefit a local charity, and this year we have selected the Durham Striders Youth Association, which provides training in track & field for local children (ages 6-18) of all backgrounds, with a particular focus on disadvantaged and minority students. The program not only enables children to develop their individual athletic potential but also to learn about discipline, leadership, sportsmanship, responsibility, and character. Combining educational programming with athletic training, the Striders program addresses important issues such as drug awareness and education, teenage sexuality, ethnic diversity, child self-protection skills, career and vocational development.For additional info and to register:http://rsvp.duke.edu/events/37th-annual-medical-families-day/custom-20-b99edc2ca011406f830ac066afcacc34.aspx

  • March 12, 2019 12:00pm to 1:00pm

    Imaging the nanoscale structure of the plasma membrane with light and electron microscopy

    Location: Bryan Research 103Justin Taraska received his B.A. in biology from Reed College in 1999 and earned his Ph.D. in cell biology from Oregon Health and Science University in 2004 in the laboratory of Wolfhard Almers. He conducted his postdoctoral research in the laboratory of William Zagotta at the University of Washington during which time he received a Jane Coffin Child Memorial Fellowship. In 2010, Dr. Taraska became a tenure-track Investigator at the NHLBI. Dr. Taraska is a 2012 PECASE recipient, the highest honor bestowed by the U.S. government on outstanding scientists and engineers beginning their independent careers. Dr. Taraska is a member of the Biophysical Society and the American Society for Cell Biology. He is also the co-director of the analytical and quantitative light microscopy course (AQLM) at the Marine Biological Lab in Woods Hole, MA.

  • March 13, 2019 12:00pm to 1:30pm

    NIH R GRANT WRITING WORKSHOP

    Location: Carpenter Conference Room, Rubenstein Library 249Attend to learn more about National Institutes of Health Research (R) grants. We will cover three main types of R grants and best practices for writing R grants. Registrants will be offered access to an R grant toolkit with templates and tools for the application process as a follow-up to this event. Lunch will be providedRegistration Required

  • March 13, 2019 12:00pm to 1:00pm

    Precision Sequencing with Single-Cell Genomics: Resolving Heterogeneity in Blood and Solid Tumors

    Location: CIEMAS Room 2240, 101 Science DriveCurrent bulk sequencing methods are inadequate to fully characterize cancer. Targeted single-cell DNA analysis resolves tumor heterogeneity, which has critical implications in understanding clonal evolution and the acquisition of therapeutic resistance.Join us to learn about the applications of the Tapestri Platform.Please send RSVP to nicolas.devos@duke.edu

  • March 19, 2019 12:00pm to 1:00pm

    Neurobiology Invited Seminar Series

    Location: Bryan Research 103Understanding how cellular and synaptic mechanisms interact within neural circuits to control behavior is a fundamental goal of neuroscience. To achieve that goal, we need a thorough understanding of behavior as well as a detailed knowledge of the underlying neural circuit. With this in mind, we focus our research on the cerebellum, a brain area that is critical for coordinated motor control and motor learning and whose circuitry is relatively simple and well understood. Many of the neuron types in the cerebellum are molecularly identifiable, and existing technologies allow us to target transgenes to specific neuronal populations. By comparing specific aspects of behavior and neural activity across mice in which we have targeted genetic perturbations to different cell types, we hope to determine links between cellular function, circuit activity, and behavior.

  • March 20, 2019 9:00am to 12:00pm

    An Overview of Risk Prediction and Classification in Omics Settings

    Location: 2240 CIEMASThis course has two objectives. First, it seeks to develop an understanding of risk prediction and classification in the Omics setting. Second, for researchers who plan to develop risk models, this course seeks to provide concrete steps for study design, analysis, and interpretation. To accomplish these goals, we will discuss how different aspects of a statistical model can provide measures of association or measures of predictive accuracy. This distinction is important in understanding how developing a model for association/etiology/causal inference is conceptually different from using the model to predict. We will then discuss risk models in the conventional setting: larger sample sizes with a smaller number of predictors. We will cover study design, statistical models, and performance metrics. The course seeks to develop an appreciation of challenging considerations in the field, but also seeks to provide clear steps on how to proceed. Finally, we will review areas of active research and in what direction the field is moving. After establishing foundations, we will move into the Omics realm, which is characterized by smaller samples sizes and thousands of predictors. Prediction models in Omics often use machine-learning techniques, so we will cover some common machine-learning techniques and what makes them different from more conventional models. We will review current best practices with an emphasis on estimating performance. This course will not include any hands-on coding because of time limitations, but this will be the topic of a future course. The course focuses on understanding the most important aspects of risk prediction and classification.

  • March 25, 2019 11:30am to 12:30pm

    “Modeling the Gene Regulatory Networks of Macrophages in Health and Disease”

    Location: 4233 French

  • March 26, 2019 12:00pm to 1:00pm

    Neurobiology Invited Seminar Series

    Location: Bryan Research 103The Moore lab focuses on identifying the neural circuits underlying fundamental perceptual and cognitive functions. Our research involves studying the activity of single neurons and large populations of neurons within the brain and testing how perturbing that activity affects neurons in other brain structures as well as how it affects the behavioral performance of behaving animals. A complementary objective of the lab is to develop and implement innovative approaches to fundamental problems in systems neuroscience.

  • April 1, 2019 11:30am to 12:30pm

    How cells break the filament bones that power their movement

    Location: 4233 French

  • April 2, 2019 12:00pm to 1:00pm

    Neurobiology Invited Seminar Series

    Location: Bryan Research 103Polley Lab is an auditory neuroscience research lab focused on the mechanisms and therapeutic potential of brain plasticity. They work on a broad portfolio of projects ranging from basic research on neural circuit dynamics in the auditory cortex up to clinical trials of auditory rehabilitation strategies for persons with debilitating perceptual disorders, such as tinnitus and hyperacusis. Their lab is part of the Eaton-Peabody Laboratories, the world's largest research center for the study of hearing and deafness.

  • April 3, 2019 1:00pm to 5:00pm

    Introduction to DNA Sequencing Technologies

    Location: 2240 CIEMASDuring the past decade, a new generation of high-throughput DNA sequencers has transformed biomedical and biotechnology research. These new technologies have fostered the development of a wide range of applications to basic and clinical research, including SNP discovery, transcriptome profiling, genome sequencing, and epigenetics. The goal of this introductory course is to teach the basic principles of next generation sequencing technology (NGS) and to present an overview of various library preparations and their applications. Advantages and limitations of various methods will be discussed and compared across technologies/platforms (Illumina, PacBio, Oxford Nanopore, Ion Torrent). This course will also provide an introduction to primary data analysis and data quality assessment steps. Attendees will become familiar with NGS technology terms and fundamentals, NGS data format and quality, and will acquire a better understanding of how to choose a suitable NGS sequencing method or instrument for their study.

  • April 8, 2019 11:30am to 12:30pm

    CBB Seminar

    Location: 4233 French

  • April 9, 2019 12:00pm to 1:00pm

    Neurobiology Invited Seminar Series

    Location: Bryan Research 103The Jayaraman lab is interested in establishing causal links between the dynamics of neural circuits and the behavioral decisions that an animal continuously makes as it navigates a multi-sensory world. They aim to uncover how the relevant neural representations and dynamics arise and what specific role they play in shaping adaptive behavior.They use the powerful genetic model organism Drosophila melanogaster for our experiments, many of which rely on monitoring and perturbing the activity of specific neural populations during head-fixed behavior. They rely on a combination of two-photon calcium imaging, whole-cell patch clamp electrophysiology, quantitative behavior, optogenetics, and computational analysis and modeling in our efforts to mechanistically link computation in a higher brain region called the central complex to the fly's behavioral decisions.

  • April 16, 2019 12:00pm to 1:00pm

    Neurobiology Invited Seminar Series

    Location: Bryan Research 103Dr. Nirao Shah is a Professor of Psychiatry and Behavioral Sciences and of Neurobiology at Stanford University. After completing his medical training, Nirao was a graduate student at Caltech, where he identified mechanisms that control differentiation of stem cells that give rise to the peripheral nervous system. For his post-graduate fellowship at Columbia University, Nirao developed genetic approaches to identify neural pathways that regulate social behaviors. In his own laboratory, his research has elaborated on such approaches to identify genes and neurons that control different aspects of social interactions. Nirao's findings have provided insights into how our brains enable social interactions in health, and they are relevant to understanding mechanisms underlying behavioral manifestations of autism, dementia, mood disorders, and PTSD.

  • April 23, 2019 12:00pm to 1:00pm

    Neurobiology Invited Seminar Series

    Location: Bryan Research 103Dr. Arenkiel is a member of the faculty at the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital. He received his bachelor's degree from St. Cloud State University in Minnesota and his doctoral degree from the University of Utah in the laboratory of Nobel Laureate Dr. Mario Capecchi, where he investigated the developmental genetic programs that function to pattern the embryonic nervous system. Dr. Arenkiel later joined the laboratory of Dr. Lawrence Katz at Duke University as a Howard Hughes postdoctoral fellow, where he investigated the neural circuitry of the mouse olfactory system. In 2010, Dr. Arenkiel joined the faculty at Baylor College of Medicine. His laboratory uses the mouse model and the feature of adult neurogenesis to investigate how neural stem cells continually form new synapses and circuits in the adult brain. The long-term goal of his research program is to devise new methods to repair or replace damaged and diseased nervous tissue.

  • April 30, 2019 12:00pm to 1:00pm

    Neurobiology Invited Seminar Series

    Location: Bryan Research 103Dr. Schaefer is an Associate Professor of Neuroscience and Psychiatry and a Seaver Fellow at the Friedman Brain Institute at Mount Sinai School of Medicine. She did her graduate studies at the Johannes Gutenberg University Mainz, the Charité University Berlin and The Rockefeller University in New York. In the fall of 2004 she joined Dr. Paul Greengard's Laboratory at The Rockefeller University where she completed her postdoctoral studies and was promoted to Research Associate in 2007 and Senior Research Associate in 2009. She joined the Friedman Brain Institute at Mount Sinai School of Medicine to start her own laboratory in 2011. Her research is focused on understanding how epigenetic mechanisms contribute to maintenance of specialized neuronal functions and their alteration during psychiatric and neurodegenerative diseases.

  • May 7, 2019 12:00pm to 1:00pm

    The Ruth K. Broad Foundation Seminar Series on Neurobiology and Disease

    Location: Bryan Research 103Research in my lab focuses on the general question of how experience acts on the nervous system to shape behavior. Our goal is to account for learning by understanding the sensory stimuli that drive change, how and where those stimuli are represented in patterns of neural activity, and how those patterns act to modify behavior. We hope both to reveal general learning mechanisms, and to understand how variations in those mechanisms give rise to individual differences in behavior. Hence, we are interested in how the nervous system changes over the course of development to give rise to 'critical periods' for learning and how innate variations between individuals interact with experience to give rise to differences in learned behaviors. Towards this end, we employ a variety of behavioral, neurophysiological and genetic approaches to investigate vocal learning in songbirds.

  • May 14, 2019 12:00pm to 1:00pm

    Neurobiology Invited Seminar Series

    Location: Bryan Research 103The goal of our laboratory is to reveal the neural basis of perception. More specifically, we want to understand exactly how cortical microcircuits process sensory information to drive behavior. While decades of research have carefully outlined how individual neurons extract specific features from the sensory environment, the cellular and synaptic mechanisms that permit ensembles of cortical neurons to actually process sensory information and generate perceptions are largely unknown.

  • May 21, 2019 12:00pm to 1:00pm

    Neurobiology Invited Seminar Series

    Location: Bryan Research 103Stress and pain-induced behavior is controlled by specific neurotransmitters and their signaling partners in the central and peripheral nervous systems. Many of these signals are conveyed through activation of neuropeptide and monoamine receptor systems. These receptors are seven transmembrane spanning G-protein coupled receptors (GPCR, also called 7 transmembrane receptors) and they engage a variety of signaling cascades following neurotransmitter release and receptor binding. To expand our knowledge of the inner workings of the brain and to identify treatments for psychiatric diseases, the Bruchas laboratory aims to dissect how GPCR systems function in the contexts of stress, depression, addiction, and pain. We strive for a greater understanding of these receptors in real time, within intact systems, and biologically relevant models of behavior. We utilize pharmacological, optogenetic, genetic, viral, imaging, behavioral, and cutting-edge engineering approaches to uncover the specific role of GPCRs and their endogenous transmitters within in vivo neural circuits that modulate affective behavior.

  • May 28, 2019 12:00pm to 1:00pm

    Larry Katz Memorial Lecture

    Location: Bryan Research 103The Andermann Lab seeks to understand how the needs of the body determine which sensory cues are attended to, learned, and remembered. In particular, they are investigating how natural and experimentally induced states of hunger modulate neural representations of food cues, and the consequences for obesity, binge eating, and other eating disorders. Previous studies support a simple model for hunger-dependent processing of food cues: During states of satiety, food cue information enters sensory neocortex but may not flow to cortical areas involved in selective processing of motivationally salient food cues, such as postrhinal cortex (POR). It has been suggested that during states of hunger, POR may be attentionally 'primed' such that food cue information spreads from visual cortex through POR to amygdala and on to lateral hypothalamic neurons involved in food-seeking behavior. They are investigating the mechanisms by which genetically, anatomically and chemically defined classes of cortical neurons facilitate cue-induced feeding in a hunger-dependent manner. Such motivation-specific priming of cortical sensory representations may arise from amygdalar and hypothalamic synaptic inputs to cortex, as well as from local hormonal and neuromodulatory actions on specific cortical neurons.

  • June 4, 2019 12:00pm to 1:00pm

    The Ruth K. Broad Foundation Seminar Series on Neurobiology and Disease

    Location: Bryan Research 103The lab's goal is to understand the interplay of membrane-bound organelles, cytoskeletal structure, and metabolism as it relates to the organization and function of neurons, and the cells they interact with. On a small scale, we are interested in mapping out the spatial organization, stoichiometry, and dynamics of proteins as they interact with each other and with different parts of the cell. On a larger scale, we are trying to decipher how complex cellular behaviors arise, including cell crawling, polarization, cell-cell contact, cytokinesis, cell fate determination, viral budding, and intercellular transfer. To study these problems, we rely heavily on microscopy - including super-resolution imaging techniques and cutting edge fluorescence-based technologies - as well as biochemistry, in vitro reconstitution, and mathematical modeling.