Computational Biology & Bioinformatics

PHD in Computational Biology & Bioinformatics

Program Principles & Goals

The Ph.D. Program in Computational Biology & Bioinformatics (CBB) is an integrative, multi-disciplinary training program that encompasses biology using computational and quantitative methods. In and out of the classroom, students learn to apply the tools of statistics, mathematics, computer science and informatics to biological problems. Vibrant and innovative research in these fields provides exciting interactions between biological and computational scientists. Because CBB is based in the Duke Center for Genomic and Computational Biology (GCB), it offers a unique opportunity for students to become tomorrow's leaders in genome sciences.

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Meet A Faculty Member

  • Associate Professor of Medicine

    Leukemias and lymphomas are malignancies that arise from immune cells. The majority of these malignancies arise from B cells, a type of immune cell. Leukemias and lymphomas derived from B cells affect over 100,000 Americans every year. The majority of those patients will succumb to their disease. Dr. Dave's research is focused on the application of high-throughput technologies including microarrays and massively parallel sequencing to improve the diagnosis and treatment of leukemias and lymphomas.
    Active efforts in the laboratory and clinic include:

    1. Integrating genomic technologies with clinical trials to define molecular subgroups of patients who are most likely to respond to therapy.
    2. Exploring the role of microRNA in the differentiation of immune cells and their role in leukemias and lymphomas.
    3. Application of high throughput sequencing to identify means of gene regulation in normal and malignant cells.
    4. Exploiting high throughput genomic and proteomic technologies to develop new prognostic and diagnostic markers in leukemias and lymphomas.

    High-throughput technologies will transform the way we diagnose and treat malignancies.

    Sandeep Dave completed an MS in Biomedical Engineering and was in the combined MD/MBA program at Northwestern University Medical School/Kellogg Graduate School of Management. After medical school, he completed a residency in internal medicine at Northwestern and a clinical and post-doctoral fellowship in hematology-oncology at the National Institutes of Health.
    He was won many awards for his research and teaching including the prestigious Fellows Award in Research Excellence at the National Institutes of Health. His work is focused on the application of high throughput technologies to identify new therapeutic targets, as well as markers of diagnosis and prognosis in patients with leukemias and lymphomas.

    Research Interests
    • Media portrayals of genomics
    • microRNA
    • Gene Regulation
    • Gene Expression Profiling
    • Leukemia and Lymphoma

Razvan Panea

3rd year CBB Student Sandeep Dave Lab
Sep 7
Brad Moore, CBB PhD Student from the Baugh Lab
CBB Student Seminar

What does every gene do?: Whole animal transposon sequencing

Sep 15
Andrea Moffitt
CBB PhD Program Dissertation Defense Seminar

Integrative Computational Genomics Defines the Molecular Origins and Outcomes of Lymphoma

Sep 19
Gevorg Grigoryan, PhD, Dartmouth University
CBB Seminar Series

Reverse Engineering Nature towards Programming Protein Molecules