Will Thompson

Will Thompson, Ph.D.
Chesterfield Building

Will Thompson

Assistant Research Professor, Proteomics and Metabolomics Shared Resource

PubMed Results

I grew up in Wilson, NC and obtained my bachelor's degree in chemistry from UNC-Wilmington in 2001, working with the MACRL group on iron speciation in rainwater. I then attended UNC-Chapel Hill for graduate school, where I received my Ph.D. in Analytical Chemistry in 2006 under the direction of Dr. Jim Jorgenson. My thesis title was Advancing Ultrahigh Pressure Liquid Chromatography Through Extensions of Theory and Practice

After graduate school I joined the Disease and Biomarker Proteomics group at GlaxoSmithKline, headed by Dr. Arthur Moseley. In 2007, Dr. Moseley was recruited to start the Proteomics and Metabolomics Shared Resource, and I was pleased to join him in this effort. Since the Proteomics and Metabolomics Shared Resource opened officially in November 2007, the lab has grown substantially (with the support of many here at Duke) and as of Spring 2015 the lab has supported over 200 principal investigators at Duke and completed nearly a thousand independent projects across all facets of quantitative and qualitative proteomics. The group has worked on a number of Biomarker studies (in areas such as Hepatitis C, Osteoarthritis, and Heart Failure), regularly perform interaction proteomics studies to define protein complexes, and work extensively to develop strategies for analysis of protein post-translational modifications (s-nitrosylation, s-acylation, acetylation, sumoylation and phosphorylation). I also enjoy implementing new commercial technologies into the regular workflow of the Proteomics and Metabolomics Shared Resource, recently these have included M-Class nanoAcquity and ionKey separation devices. I am currently working with Laura Dubois and Lisa St. John-Williams to signficantly expand the facility's capabilities in metabolite and lipid quantification. As of Spring 2015 the metabolomics platforms include unbiased lipid profiling, Biocrates Absolute IDQ p180 and bile acid platforms, a custom Methionine pathway panel, a hydroxycholesterols panel, and an eicosanoid/oxylipin panel.

I also enjoy collaborations with groups out of Duke, particularly in the development of new technologies for proteomics and metabolomics data collection and analysis. The Skyline software tool, developed by Brendan MacLean and his team in the MacCoss laboratory at the University of Washington, is an exciting new software package for SRM and full-scan MS quantitative analysis. I was pleased to participate in 2012 at the first (annual) Skyline ASMS user's meeting in Vancouver. If you are interested in the proceedings of this meeting, Brendan recorded it and made the presentations available here.

In leisure time, one of my favorite activities is cooking authentic North Carolina Barbeque. If you want to give it a try on your own, I highly recommend the book Holy Smoke cowritten by Will McKinney (founder of the Carolina BBQ Society at UNC), as a great starting point.