Jason Locasale, PhD

Jason Locasale

Jason Locasale, PhD

Assistant Professor of Pharmacology & Cancer Biology

Our lab is part of the Department of Pharmacology and Cancer Biology at Duke University.  We are also members of the Duke Cancer Institute and the Duke Molecular Physiology Institute.  We have a longstanding interest in understanding the structure and function of metabolic networks in health and pathology.  We are a diverse group with equally diverse skills in analytical chemistry, genetics, computational biology, bioinformatics, and mathematics, and biochemistry allowing us to solve complex biological problems with an integrative and collaborative approach. 

Our research focuses on an integrated understanding of metabolism in health and disease.  We direct these efforts toward understanding the role of altered metabolism in cancer, emphasizing its targetable liabilities and downstream effects on cellular physiology, notably its influence on the chromatin state.  At the core of this effort lies the utilization of computational modeling and high throughput technologies such as mass spectrometry-based metabolomics.  We define our systems biology approach through combining these tools with an integration of genetics, biochemistry, and cell biology.  Investing such effort we believe has the potential to fundamentally alter our understanding of disease biology and lead to innovative therapies.  

Recent Publications

Freemerman, AJ; Zhao, L; Pingili, AK; Teng, B; Cozzo, AJ; Fuller, AM; Johnson, AR; Milner, JJ; Lim, MF; Galanko, JA; Beck, MA; Bear, JE; Rotty, JD; Bezavada, L; Smallwood, HS; Puchowicz, MA; Liu, J; Locasale, JW; Lee, DP; Bennett, BJ; Abel, ED; Rathmell, JC; Makowski, L
February 1, 2019
Hart, PC; Chiyoda, T; Liu, X; Weigert, M; Curtis, M; Chiang, C-Y; Loth, R; Lastra, R; McGregor, SM; Locasale, JW; Lengyel, E; Romero, IL
January 17, 2019
May, JL; Kouri, FM; Hurley, LA; Liu, J; Tommasini-Ghelfi, S; Ji, Y; Gao, P; Calvert, AE; Lee, A; Chandel, NS; Davuluri, RV; Horbinski, CM; Locasale, JW; Stegh, AH
January 2, 2019
Curtis, M; Kenny, HA; Ashcroft, B; Mukherjee, A; Johnson, A; Zhang, Y; Helou, Y; Batlle, R; Liu, X; Gutierrez, N; Gao, X; Yamada, SD; Lastra, R; Montag, A; Ahsan, N; Locasale, JW; Salomon, AR; Nebreda, AR; Lengyel, E
January 1, 2019
Gemta, LF; Siska, PJ; Nelson, ME; Gao, X; Liu, X; Locasale, JW; Yagita, H; Slingluff, CL; Hoehn, KL; Rathmell, JC; Bullock, TNJ
January 1, 2019
Reid, MA; Allen, AE; Liu, S; Liberti, MV; Liu, P; Liu, X; Dai, Z; Gao, X; Wang, Q; Liu, Y; Lai, L; Locasale, JW
December 21, 2018