919-681-9184

Xiling Shen, PhD

Associate Professor, Biomedical Engineering

Specialized in precision medicine and systems biology, the Shen lab integrates engineering, computational and biological techniques to study cancer, stem cells, microbiota, and the nervous system in the gut

The Shen lab uses systems biology to study spatiotemporal controls of multicellular systems, and how their subversion lead to diseases. Ongoing projects include colon cancer, normal and cancer stem cells, non-coding RNAs, enteric nervous system, and tuberculosis.

Originally trained as an electrical engineer, Dr. Shen studies biological circuits that are critical to development and diseases. He also develops novel technologies that model human diseases and enable single-cell tracking in live animals.

Research Interests

Stem Cells

Cancer

Non-Coding RNA

Systems Biology

Recent Publications

The frontier of live tissue imaging across space and time

Huang, Q; Garrett, A; Bose, S; Blocker, S; Rios, AC; Clevers, H; Shen, X

April 1, 2021

Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.

McClain, MT; Constantine, FJ; Henao, R; Liu, Y; Tsalik, EL; Burke, TW; Steinbrink, JM; Petzold, E; Nicholson, BP; Rolfe, R; Kraft, BD; Kelly, MS; Saban, DR; Yu, C; Shen, X; Ko, EM; Sempowski, GD; Denny, TN; Ginsburg, GS; Woods, CW

February 17, 2021

The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants.

Dohlman, AB; Arguijo Mendoza, D; Ding, S; Gao, M; Dressman, H; Iliev, ID; Lipkin, SM; Shen, X

February 10, 2021

Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity.

Sarvestani, SK; Signs, S; Hu, B; Yeu, Y; Feng, H; Ni, Y; Hill, DR; Fisher, RC; Ferrandon, S; DeHaan, RK; Stiene, J; Cruise, M; Hwang, TH; Shen, X; Spence, JR; Huang, EH

January 11, 2021

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.

Wang, L; Balmat, TJ; Antonia, AL; Constantine, FJ; Henao, R; Burke, TW; Ingham, A; McClain, MT; Tsalik, EL; Ko, ER; Ginsburg, GS; DeLong, MR; Shen, X; Woods, CW; Hauser, ER; Ko, DC

December 22, 2020

Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity.

Giroux, NS; Ding, S; McClain, MT; Burke, TW; Petzold, E; Chung, HA; Palomino, GR; Wang, E; Xi, R; Bose, S; Rotstein, T; Nicholson, BP; Chen, T; Henao, R; Sempowski, GD; Denny, TN; Ko, ER; Ginsburg, GS; Kraft, BD; Tsalik, EL; Woods, CW; Shen, X

December 5, 2020