My research involves identifying gene regulatory elements across the genome to help us understand how chromatin structure dictates cell function and fate. For the last 30 years, mapping DNase I hypersensitive sites has been the gold standard method to identify the location of active regulatory elements, including promoters, enhancers, silencers, and locus control regions. I have developed technologies that can identify most DNase I hypersensitive sites from potentially any cell type from any species with a sequenced genome. We are combining this data with other wet-lab and computational data types to better understand how these regulatory regions control global gene expression in a set of diverse tissues (normal and diseased) representative of the human body.
Greg Crawford, Ph.D., is an Associate Professor in the Department of Pediatrics and the GCB. He received his Ph.D. from the University of Michigan in 2001. Afterwards, he was a post-doctoral fellow in the lab of Dr. Francis Collins at the National Human Genome Research Institute, where he developed novel technologies to identify active gene regulatory elements on a genome-wide scale. He joined the Duke faculty in March 2006.