Advisor: Charles Gersbach, Ph.D., Department of Biomedical Engineering
The Gersbach lab focuses on developing and applying innovating methods in genetic engineering towards therapeutic avenues for treatment of genetic diseases and enhancing of our understanding of biological processes. These efforts are largely centralized upon coordinating changes at the genetic level in order to achieve more efficient and robust control of cell behavior. To this end, we will develop and characterize Cas9-fusion systems and examine their ability to control gene expression. We plan to also explore the potential for improved activation through the combination of activator systems, and assess the role of cooperativity in maximizing gene expression.