Exploring a New World of Social Data
This summer, a group of statisticians, mathematicians, and engineers will move into Gross Hall, one floor up from SSRI West. The group is collaborating to build a Big Data ...
Computational Biology
As the technology continues to improve and the costs to drop, making sense of the overload of information pouring out of genome studies will increasingly depend on close collaborations between genome scientists and those with the quantitative skills needed to distill meaning out of mass quantities of data.
To that end, computational biologists at the IGSP are focusing on solutions for analyzing data from genome-wide studies, as well as gene expression and proteomic data. IGSP investigators are developing the computational, statistical and bioinformatic tools required to find meaningful patterns in DNA sequence. IGSP collaborations are also providing quantitative insights into network dynamics, a fundamental problem in systems biology. Many of the software tools our researchers have developed are made freely available to other scientists around the globe.
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Bioengineers Recreate Natural Complex Gene Regulation
By reproducing in the laboratory the complex interactions that cause human genes to turn on inside cells, Duke University bioengineers have created a system they believe can benefit ...
Fragile X Protein Linked to Nearly 100 Genes Involved in Autism
Doctors have known for many years that patients with fragile X syndrome, the most common form of inherited intellectual disability, are often also diagnosed with autism. But little ...
Tim Reddy: The Basis for Differences
“If you look at a lot of disease studiesa lot of the genetic variation that’s associated with disease risk [seems to be] more likely to ...
Related Publications
Unsupervised Bayesian Linear Unmixing of Gene Expression Microarrays
Geoff Ginsburg is a collaborator on a study introducing a new constrained model and the corresponding algorithm to identify biological signatures from high-dimensional assays like gene ...
The Chromosome 3q25 Genomic Region is Associated with Measures of Adiposity in Newborns in Multi-Ethnic Genome Wide Association Study
Tim Reddy is a collaborator on a study suggesting that the association of a genomic region with birth weight is secondary to its effect on fat versus lean body mass.
Genomic Regions Flanking E-Box Binding Sites Influence DNA Binding Specificity of bHLH Transcription Factors through DNA Shape
Raluca Gordan is lead author of a study that used custom protein-binding microarrays to analyze transcription factor specificity for putative binding sites in their genomic sequence ...
Patterns of Regulatory Activity Across Diverse Human Cell-Types Predict Tissue Identity, Transcription Factor Binding, and Long-Range Interactions
Greg Crawford, Terry Furey and Nathan Sheffield developed a classifier that accurately predicts cell-type lineage based on only 43 DNaseI-hypersensitive sites and used it to evaluate ...
Clinical and Biological Relevance of Genomic Heterogeneity in Chronic Lymphocytic Leukemia
Joe Lucas is an author of a report on the extent of genomic variability in chronic lymphocytic leukemia and the biological and clinical attributes of genomic classification of the ...
