In Oncogene, Joe Nevins and colleagues say that the genetic alterations underlying tumor progression and an escape from Myc-dependent growth in a transgenic mouse model can provide insights into what occurs in human cancers as they acquire drug resistance and metastatic properties.
In Genome Research, Uwe Ohler and Philip Benfey present small RNA datasets comprising over 200 million aligned Illumina sequence reads covering all major cell types of the root as well as four distinct developmental zones.
In Genome Research, Sayan Mukherjee is a collaborator on a paper describing a single statistical framework, Gene Set Association Analysis (GSAA), that simultaneously measures genome-wide patterns of genetic variation and gene expression variation to identify sets of genes enriched for differential expression and/or trait-associated genetic markers.
In The Annual Review of Genomics and Human Genetics, Isaac Chan and Geoff Ginsburg focus on providing a comprehensive understanding of personalized medicine, from scientific discovery at the laboratory bench to integration of these novel ways of understanding human biology at the bedside.
In Science Translational Medicine, Geoff Ginsburg and Amy Abernethy say academic medical centers can play a central role in the transformation of health care through the development of rapid learning environments, evidence generation, implementation research, and education of health professionals and the public.
In Cell Cycle, Lingchong You and colleagues discuss how network modules contribute to 'shaping' E2F dynamics in the context of mammalian cell cycle entry.
In Science, Bob Cook-Deegan writes, "It is no secret that U.S. health care is expensive, unfairly distributed, and highly inefficient compared with that of other developed economies," the question is "how to address this problem without gutting the parts of the U.S. health-research infrastructure that are working well."
Collaborative competitions in which communities of researchers compete to solve challenges may facilitate more rigorous scrutiny of scientific results, say researchers including Alex Hartemink in a Nature Biotechnology commentary.
In PLoS Pathogens, Fred Dietrich is a collaborator on a study that examined the molecular epidemiology, population structure, and virulence attributes of Cryptococcus gattii isolates collected from HIV/AIDS patients in Los Angeles County, California.
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