David B. Goldstein, PhD
Publications
Fellay J, Shianna KV, Ge D, Colombo S, Ledergerber B, Weale M, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, De Luca A, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Goldstein DB.
A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1.
Science. 2007 Jul 19; [Epub ahead of print]
PMID: 17641165 [PubMed - as supplied by publisher]
Fellay J, Goldstein DB.
Host genetics: fine-tuning innate signaling.
Curr Biol. 2007 Jul 3;17(13):R516-8.
PMID: 17610834 [PubMed - in process]
Cirulli ET, Goldstein DB.
in vitro assays fail to predict in vivo effects of regulatory polymorphisms.
Hum Mol Genet. 2007 Jun 12; [Epub ahead of print]
PMID: 17566082 [PubMed - as supplied by publisher]
Kasperaviciute D, Weale ME, Shianna KV, Banks GT, Simpson CL, Hansen VK, Turner MR, Shaw CE, Al-Chalabi A, Pall HS, Goodall EF, Morrison KE, Orrell RW, Beck M, Jablonka S, Sendtner M, Brockington A, Ince PG, Hartley J, Nixon H, Shaw PJ, Schiavo G, Wood NW, Goldstein DB, Fisher EM.
Large-scale pathways-based association study in amyotrophic lateral sclerosis.
Brain. 2007 Apr 23; [Epub ahead of print]
PMID: 17439985 [PubMed - as supplied by publisher]
Cavalleri GL, Walley NM, Soranzo N, Mulley J, Doherty CP, Kapoor A, Depondt C, Lynch JM, Scheffer IE, Heils A, Gehrmann A, Kinirons P, Gandhi S, Satishchandra P, Wood NW, Anand A, Sander T, Berkovic SF, Delanty N, Goldstein DB, Sisodiya SM.
A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy.
Epilepsia. 2007 Apr;48(4):706-12.
PMID: 17437413 [PubMed - indexed for MEDLINE]
Soranzo N, Kelly L, Martinian L, Burley MW, Thom M, Sali A, Kroetz DL, Goldstein DB, Sisodiya SM.
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.
Epilepsia. 2007 Apr;48(4):674-83.
PMID: 17437410 [PubMed - indexed for MEDLINE]
Heinzen EL, Yoon W, Tate SK, Sen A, Wood NW, Sisodiya SM, Goldstein DB.
Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A.
Am J Hum Genet. 2007 May;80(5):876-83. Epub 2007 Apr 3.
PMID: 17436242 [PubMed - indexed for MEDLINE]
Goldstein DB, Need AC, Singh R, Sisodiya SM.
Potential genetic causes of heterogeneity of treatment effects.
Am J Med. 2007 Apr;120(4 Suppl 1):S21-5. Review.
PMID: 17403378 [PubMed - indexed for MEDLINE]
Heinzen EL, Yoon W, Weale ME, Sen A, Wood NW, Burke JR, Welsh-Bohmer KA, Hulette CM, Sisodiya SM, Goldstein DB.
Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease.
Genome Biol. 2007;8(3):R32.
PMID: 17343748 [PubMed - indexed for MEDLINE]
Sisodiya SM, Thompson PJ, Need A, Harris SE, Weale ME, Wilkie SE, Michaelides M, Free SL, Walley N, Gumbs C, Gerrelli D, Ruddle P, Whalley LJ, Starr JM, Hunt DM, Goldstein DB, Deary IJ, Moore AT.
Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation.
J Med Genet. 2007 Jun;44(6):373-80. Epub 2007 Jan 19.
PMID: 17237123 [PubMed - indexed for MEDLINE]
Need AC, Goldstein DB.
Genome-wide tagging for everyone.
Nat Genet. 2006 Nov;38(11):1227-8. No abstract available.
PMID: 17072295 [PubMed - indexed for MEDLINE]
Telenti A, Goldstein DB.
Genomics meets HIV-1.
Nat Rev Microbiol. 2006 Nov;4(11):865-73. Epub 2006 Oct 9.
PMID: 17041633 [PubMed - indexed for MEDLINE]
Tate SK, Singh R, Hung CC, Tai JJ, Depondt C, Cavalleri GL, Sisodiya SM, Goldstein DB, Liou HH.
A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose.
Pharmacogenet Genomics. 2006 Oct;16(10):721-726.
PMID: 17001291 [PubMed - as supplied by publisher]
Kinirons P, Cavalleri GL, Shahwan A, Wood NW, Goldstein DB, Sisodiya SM, Delanty N, Doherty CP.
Examining the role of common genetic variation in the gamma2 subunit of the GABA(A) receptor in epilepsy using tagging SNPs.
Epilepsy Res. 2006 Aug;70(2-3):229-38. Epub 2006 Jun 27.
PMID: 16806831 [PubMed - indexed for MEDLINE]
Kinirons P, Cavalleri GL, Singh R, Shahwan A, Acheson JF, Wood NW, Goldstein DB, Sisodiya SM, Doherty CP, Delanty N.
A pharmacogenetic exploration of vigabatrin-induced visual field constriction.
Epilepsy Res. 2006 Aug;70(2-3):144-52. Epub 2006 May 3.
PMID: 16675198 [PubMed - indexed for MEDLINE]
Need AC, Ahmadi KR, Spector TD, Goldstein DB.
Obesity is associated with genetic variants that alter dopamine availability.
Ann Hum Genet. 2006 May;70(Pt 3):293-303.
PMID: 16674552 [PubMed - indexed for MEDLINE]
Capelli C, Redhead N, Romano V, Cali F, Lefranc G, Delague V, Megarbane A, Felice AE, Pascali VL, Neophytou PI, Poulli Z, Novelletto A, Malaspina P, Terrenato L, Berebbi A, Fellous M, Thomas MG, Goldstein DB.
Population structure in the Mediterranean basin: a Y chromosome perspective.
Ann Hum Genet. 2006 Mar;70(Pt 2):207-25.
PMID: 16626331 [PubMed - indexed for MEDLINE]
Shah PR, Ahmad-Annuar A, Ahmadi KR, Russ C, Sapp PC, Horvitz HR, Brown RH Jr, Goldstein DB, Fisher EM.
No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach.
Amyotroph Lateral Scler. 2006 Mar;7(1):46-56.
PMID: 16546759 [PubMed - indexed for MEDLINE]
Ozawa T, Healy DG, Abou-Sleiman PM, Ahmadi KR, Quinn N, Lees AJ, Shaw K, Wullner U, Berciano J, Moller JC, Kamm C, Burk K, Josephs KA, Barone P, Tolosa E, Goldstein DB, Wenning G, Geser F, Holton JL, Gasser T, Revesz T, Wood NW; European MSA study group.
The alpha-synuclein gene in multiple system atrophy.
J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):464-7.
PMID: 16543523 [PubMed - indexed for MEDLINE]
Healy DG, Abou-Sleiman PM, Casas JP, Ahmadi KR, Lynch T, Gandhi S, Muqit MM, Foltynie T, Barker R, Bhatia KP, Quinn NP, Lees AJ, Gibson JM, Holton JL, Revesz T, Goldstein DB, Wood NW.
UCHL-1 is not a Parkinson's disease susceptibility gene.
Ann Neurol. 2006 Apr;59(4):627-33.
PMID: 16450370 [PubMed - indexed for MEDLINE]
Ho GT, Soranzo N, Nimmo ER, Tenesa A, Goldstein DB, Satsangi J.
ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach.
Hum Mol Genet. 2006 Mar 1;15(5):797-805. Epub 2006 Jan 24.
PMID: 16434479 [PubMed - indexed for MEDLINE]
Andersson T, Flockhart DA, Goldstein DB, Huang SM, Kroetz DL, Milos PM, Ratain MJ, Thummel K.
Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests.
Clin Pharmacol Ther. 2005 Dec;78(6):559-81. Review. No abstract available.
PMID: 16338273 [PubMed - indexed for MEDLINE]
Rockman MV, Hahn MW, Soranzo N, Zimprich F, Goldstein DB, Wray GA.
Ancient and recent positive selection transformed opioid cis-regulation in humans.
PLoS Biol. 2005 Dec;3(12):e387.
PMID: 16274263 [PubMed - indexed for MEDLINE]
Goldstein DB, Cavalleri GL.
Genomics: understanding human diversity.
Nature. 2005 Oct 27;437(7063):1241-2. No abstract available.
PMID: 16251937 [PubMed - indexed for MEDLINE]
Gandhi S, Abou-Sleiman PM, Healy DG, Weale M, Gilks W, Ahmadi K, Goldstein DB, Wood NW.
Population genetic approaches to neurological disease: Parkinson's disease as an example.
Philos Trans R Soc Lond B Biol Sci. 2005 Aug 29;360(1460):1573-8. Review.
PMID: 16096106 [PubMed - indexed for MEDLINE]
Goldstein DB.
The genetics of human drug response.
Philos Trans R Soc Lond B Biol Sci. 2005 Aug 29;360(1460):1571-2. Review.
PMID: 16096105 [PubMed - indexed for MEDLINE]
Stumpf MP, Goldstein DB, Wood NW.
Introduction: genetic variation and human health.
Philos Trans R Soc Lond B Biol Sci. 2005 Aug 29;360(1460):1539-41. No abstract available.
PMID: 16096101 [PubMed - indexed for MEDLINE]
Soranzo N, Bufe B, Sabeti PC, Wilson JF, Weale ME, Marguerie R, Meyerhof W, Goldstein DB.
Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16.
Curr Biol. 2005 Jul 26;15(14):1257-65.
PMID: 16051168 [PubMed - indexed for MEDLINE]
Soranzo N, Goldstein DB, Sisodiya SM.
The role of common variation in drug transporter genes in refractory epilepsy.
Expert Opin Pharmacother. 2005 Jul;6(8):1305-12. Review.
PMID: 16013981 [PubMed - indexed for MEDLINE]
Healy DG, Abou-Sleiman PM, Quinn N, Ahmadi KR, Ozawa T, Kamm C, Wullner U, Oertel WH, Burk K, Dupont E, Pellecchia MT, Tolosa E, Gasser T, Holton JL, Revesz T, Goldstein DB, Lees AJ, Wood NW; European MSA Study Group.
UCHL-1 gene in multiple system atrophy: a haplotype tagging approach.
Mov Disord. 2005 Oct;20(10):1338-43.
PMID: 16007636 [PubMed - indexed for MEDLINE]
Goldstein DB.
Haplotype tagging in pharmacogenetics.
Novartis Found Symp. 2005;267:14-9; discussion 19-30.
PMID: 15999798 [PubMed - indexed for MEDLINE]
Need AC, Motulsky AG, Goldstein DB.
Priorities and standards in pharmacogenetic research.
Nat Genet. 2005 Jul;37(7):671-81. Review.
PMID: 15990888 [PubMed - indexed for MEDLINE]
Sisodiya S, Soranzo N, Wood NW, Goldstein DB.
Association of genetic loci: replication or not, that is the question.
Neurology. 2005 Jun 14;64(11):1989. No abstract available.
PMID: 15955969 [PubMed - indexed for MEDLINE]
Cavalleri GL, Lynch JM, Depondt C, Burley MW, Wood NW, Sisodiya SM, Goldstein DB.
Failure to replicate previously reported genetic associations with sporadic temporal lobe epilepsy: where to from here?
Brain. 2005 Aug;128(Pt 8):1832-40. Epub 2005 May 11.
PMID: 15888540 [PubMed - indexed for MEDLINE]
Tate SK, Depondt C, Sisodiya SM, Cavalleri GL, Schorge S, Soranzo N, Thom M, Sen A, Shorvon SD, Sander JW, Wood NW, Goldstein DB.
Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin.
Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5507-12. Epub 2005 Apr 1.
PMID: 15805193 [PubMed - indexed for MEDLINE]
Ahmadi KR, Weale ME, Xue ZY, Soranzo N, Yarnall DP, Briley JD, Maruyama Y, Kobayashi M, Wood NW, Spurr NK, Burns DK, Roses AD, Saunders AM, Goldstein DB.
A single-nucleotide polymorphism tagging set for human drug metabolism and transport.
Nat Genet. 2005 Jan;37(1):84-9. Epub 2004 Dec 19.
PMID: 15608640 [PubMed - indexed for MEDLINE]
Goldstein DB, Hirschhorn JN.
In genetic control of disease, does 'race' matter?
Nat Genet. 2004 Dec;36(12):1243-4. No abstract available.
PMID: 15565101 [PubMed - indexed for MEDLINE]
Tate SK, Goldstein DB.
Will tomorrow's medicines work for everyone?
Nat Genet. 2004 Nov;36(11 Suppl):S34-42. Review.
PMID: 15508001 [PubMed - indexed for MEDLINE]
Depondt C, Cock HR, Healy DG, Burley MW, Weinshenker D, Wood NW, Goldstein DB, Sisodiya SM.
The -1021C->T DBH gene variant is not associated with epilepsy or antiepileptic drug response.
Neurology. 2004 Oct 26;63(8):1497-9.
PMID: 15505174 [PubMed - indexed for MEDLINE]
Barbujani G, Goldstein DB.
Africans and Asians abroad: genetic diversity in Europe.
Annu Rev Genomics Hum Genet. 2004;5:119-50. Review.
PMID: 15485345 [PubMed - indexed for MEDLINE]
Contact Information
David B. Goldstein
IGSP Center for Human Genome Variation
IGSP, Duke University
450 Research Drive, Box 91009
LSRC B Wing, Room 330
Durham, NC 27708
(P) 919-684-0896
Angelique Cherry
Assistant to Dr. Goldstein
Phone: 919-684-0896
330 LSRC B Wing
angelique.cherry@duke.edu