Brian Chadwick, PhD
Assistant Research Professor, Cell Biology
"I' m interested in how DNA of the human inactive X chromosome is packaged into heterochromatin to switch off gene expression, and how this configuration is faithfully maintained throughout all subsequent cell divisions."Brian Chadwick, PhD, is an IGSP Scholar and an Assistant Research Professor in Cell Biology. Brian received his PhD from Imperial Cancer Research Fund and the University of London in 1997, working under the supervision of Professor Anna-Marie Frishchauf, where he helped map disease genes on human chromosome 9. He continued this research as a post-doctoral research fellow in the Molecular Neurogenetics Unit at Massachusetts General Hospital and Harvard Medical School.
In his second post-doctoral position at Case Western Reserve under Huntington Willard, Brian became interested in heterochromatin organization of the human inactive X chromosome (Xi) and discovered that the human Xi heterochromatin is packaged into at least two spatially distinct forms of heterochromatin that occupy defined regions of the X chromosome.
His current research includes the investigation of the relationship between the two heterochromatin types, with particular emphasis upon differences in gene silencing and DNA replication timing using RNA-interference. Brian is also focusing on the organization of chromatin between the territories and the role it might play in maintaining the surrounding chromatin.
Contact Information
Brian Chadwick
Phone: 919 684-2634
4008 GSRB II
brian.chadwick@duke.edu