Cyclin-Dependent Kinases Are Regulators and Effectors of Oscillations Driven by a Transcription Factor Network
Laura Simmons Kovacs, Sayan Mukherjee and Steve Haase report a model in Molecular Cell in which cyclin expression is entrained to an autonomous transcriptional oscillator.
The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines
In PLoS Pathogens, Uwe Ohler is a collaborator on a study revealing that Epstein-Barr virus miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment.
Time-Dependent Changes in Non-COX-1-Dependent Platelet Function with Daily Aspirin Therapy
Deepak Voora, Geoff Ginsburg and colleagues measured the temporal response to aspirin in healthy volunteers and diabetics with results reported in the Journal of Thrombosis and Thrombolysis.
Etiological Features of Borderline Personality Related Characteristics in a Birth Cohort of 12-Year-Old Children
In Developmental Psychopathology, Terrie Moffitt and Avshalom Caspi report evidence to suggest that inherited and environmental risk factors make independent and interactive contributions to borderline etiology.
Effects of Sequence Variation on Differential Allelic Transcription Factor Occupancy and Gene Expression
In Genome Research, Tim Reddy led a study with collaborators Greg Crawford, Hunt Willard and others that highlights the potential for allelic differences in transcription factor occupancy to give functional insights into intergenic variants associated with disease.
Dissecting the Regulatory Architecture of Gene Expression QTLs
In Genome Biology, Greg Crawford is a collaborator on a study that demonstrates how regulatory annotation and the association signal derived from eQTL-mapping can be combined into a single framework.
DNaseI Sensitivity QTLs Are a Major Determinant of Human Expression Variation
Greg Crawford is a collaborator of a study in Nature indicating that dsQTLs are highly abundant in the human genome and are likely to be important contributors to phenotypic variation.
Transcriptional Switches Direct Plant Organ Formation and Patterning
Philip Benfey and colleagues review recent literature of switches operating in cell fate decisions that are regulated by transcriptional mechanisms in Current Topics in Developmental Biology.
Engineering Microbial Systems to Explore Ecological and Evolutionary Dynamics
In Current Opinion in Biotechnology, Lingchong You and colleagues present recent developments in engineered microbial systems and discuss how they were used to address problems in ecology and evolutionary biology.
Using Confirmatory Factor Analysis to Measure Contemporaneous Activation of Defined Neuronal Networks in Functional Magnetic Resonance Imaging
In Neuroimage, Ahmad Hariri and colleagues say that confirmatory factor analysis is a convenient hypothesis-driven modeling environment that can be used to conduct formal statistical tests comparing alternative hypotheses regarding the elements of putative neuronal networks.
Imaging Genetics and the Neurobiological Basis of Individual Differences in Vulnerability to Addiction
In Drug and Alcohol Dependence, Ahmad Hariri and colleagues conclude that variation in genes related to dopamine signaling may contribute to heterogeneity in the brain's sensitivity to reward and, ultimately, to addiction.
Uncoupling of Genomic and Epigenetic Signals in the Maintenance and Inheritance of Heterochromatin Domains in Fission Yeast
In Genetics, Bayly Wheeler, Brandon Ruderman, Hunt Willard and Kristin Scott report evidence for chromatin-dependent, epigenetic control of gene silencing that is heritable, stable, and self-sustaining, even in the absence of the originating genomic signals.
Characterization of an Oxaliplatin Sensitivity Predictor in a Preclinical Murine Model of Colorectal Cancer
In Molecular Cancer Therapy, David Hsu and colleagues present findings to suggest that patient-derived colorectal cancer explants can be a novel source to study drug sensitivity in vivo.
Characterization of the Poly-T Variant in the TOMM40 Gene in Diverse Populations
In PLoS One, Ornit Chiba-Falek and Allen Roses explore the frequency of TOMM40 variants earlier associated with age-of-onset of Alzheimer's disease in diverse populations.
Discovery of a Modified Tetrapolar Sexual Cycle in Cryptococcus amylolentus and the Evolution of MAT in the Cryptococcus Species Complex
In PLoS Genetics, Fred Dietrich and Joe Heitman report studies that reveal insights into the plasticity and transitions in sex determination and sexual reproduction in Cryptococcus with implications for similar evolutionary transitions and processes in fungi, plants and animals.