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Hunting Tailored Care For Advanced Prostate Cancer
In this New York Times article, Phil Febbo describes his efforts to decode prostate cancer's tricks by looking directly at the tumor’s genetic signature.
Genetic Irregularities Linked to Higher Risk of COPD Among Smokers
David Goldstein and his research team have discovered two genetic variants on chromosome 15 that are associated with an increased risk of chronic obstructive pulmonary disease (COPD), especially in smokers. The work was published in PLoS Genetics.
What's Driving Specific Patterns of Gene Expression Among Cell Types?
A nationwide research team that included Greg Crawford has identified and mapped 55,000 enhancers in the human genome. The map will help scientists understand how cells control expression of genes specific to their particular cell type. The study was published in Nature.
Q&A With Misha Angrist
Misha Angrist discusses with The Chronicle his participation in The Personal Genome Project.
When Genes Cooperate, Lung Cancer Grows and Spread
David Hsu, a fellow in Phil Febbo's lab, explains his findings that three genes actually work together to provide an environment conductive to the growth and proliferation of cancer cells. This work was featured in PLoS.
Genomic Clinical Trials
Phil Febbo and IGSP Member David Harpole are using a patient's genome to determine what treatment will likely be successful for that patient. This Duke Comprehensive Cancer Center story features two clinical trials studies that focus on the personalized care of patients.
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The Dangers of Diagnostic Monopolies
In this commentary published in Nature, Bob Cook-Deegan, Subhashini Chandrasekharan and Misha Angrist observe that, contrary to predictions by some, patenting of genes has not resulted in a pattern of exorbitant pricing or restricted access to tests for diseases such as Alzheimer’s and breast cancer. Nonetheless, patents and exclusive licenses that establish genetic testing monopolies are creating significant problems for patients and physicians.
Genomic Strategy for Targeting Therapy in Castration-Resistant Prostate Cancer
In this Journal of Clinical Oncology publication, lead author Phil Febbo concluded that a transcription-based androgen receptor signature within individual prostate cancer specimens has the potential to help individualize and improve care for patients with castration-resistant prostate cancer.
Both the Conserved GRAS Domain and Nuclear Localization are Required for SHORT-ROOT Movement
Philip Benfey and Kimberly Gallagher report in Plant their surprising discovery that the capacity for intercellular movement may be conserved among other GRAS family proteins. In addition, evidence is provided that movement requires both cytoplasmic and nuclear localization, strongly suggesting a mechanistic link between nuclear transport and cell-to-cell movement.
Polymorphisms of the Scavenger Receptor Class B Member 1 are Associated With Insulin Resistance with Evidence of Gene by Sex Interaction
Jeanette McCarthy is lead investigator on a gene x sex interaction study, published in the Journal of Clinical Endocrinology and Metabolism, which found an association between SCARB1 variants and insulin resistance.
Assembling Heterochromatin in the Appropriate Places: A Boost is Needed
Laura Rusche and Patrick Lynch review in the Journal of Cellular Physiology two aspects of silenced chromatin that have been under-appreciated.
Biotech Under Obama
Robert Cook-Deegan comments in this Nature Biotechnology feature that expresses optimism with the Obama administration on its efforts regarding biotech policies. |
Justin Guinney, a CBB graduate student in Phil Febbo's and Sayan Mukherjee's research programs, received a two-year training award from the Department of Defense to focus his efforts on the development of statistical methods and software assessing gene dependencies in prostate cancer.
David Goldstein received a one-year supplement to his previous NIH CHAVI award.
Ashley Chi received a one-year grant from the Gates Foundation for a project entitled "Mis-expression of liver-specific miRNAs to eradicate malaria". |
NIH Announces the Availability of Recovery Act Funds for Administrative Supplements (NOT-OD-09-056)
American Reinvestment and Recovery Act of 2009
NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications (NOT-OD-09-058)
American Reinvestment and Recovery Act of 2009
NIH Announces the Availability of Recovery Act Funds for Administrative Supplements Providing Summer Research Experiences for Students and Science Educators (NOT-OD-09-060)
American Reinvestment and Recovery Act of 2009
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For full details and the latest updates on IGSP seminars and events, see the Events Calendar
A selection of upcoming events:
Wednesday, April 1st
Genome Academy
Rob Wagner, Senior Database Administrator IGSP, will present "Introduction to Oracle".
Wednesday, April 1st
Systems Biology Seminar
Maggie Werner-Washburne, University of New Mexico will present "The genomics of yeast stationary phase: what you don't know could hurt you!"
Wednesday, April 1st
Computational Biology Seminar
Nicolas Buchler, Rockefeller University, will present "Bait and switch: How protein sequestration generates a flexible ultrasensitive response".
Thursday, April 2nd
Genomic Medicine Forum
Subhashini Chandrasekharan, PhD will present "Intellectual Property Challenges for Development of Genomic Diagnostics".
Tuesday, April 7th
Distinguished Alumni Lecture
Amy S. Gladfelter, PhD from Dartmouth College, will present "Nuclear Anarchy: The Power of Variability in the Cell Cycle".
Tuesday, April 7th
Genome Biology Meeting
Alan Boyle from the Furey Lab presents.
Thursday, April 14th
Tuesday Seminar Series
Laura Landweber, Princeton University, will present "RNA-mediated epigenetic programming of genome rearrangement". |
RFA-OD-09-003 - Recovery Act Limited Competition: NIH Challenge Grants in Health and Science Research (RC1)
Application Due Date: April 27, 2009
Opening Date: March 27, 2009 (Earliest date an application may be submitted to Grants.gov).
PAR-09-118 - Recovery Act Limited Competition: High-End Instrumentation Grant Program (S10)
For a single major item of equipment to be used for biomedical research that costs between $600,000 - $8,000,000
Letters of Intent Due: April 6, 2009
Application Due: May 6, 2009 |
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The final issue of GenomeLIFE for this academic year is now available. This 12-page issue includes a feature story about genome sequencing studies of HIV-resistant patients in the IGSP Center for Human Genome Variation. Read how a person's sex can alter the way their genes influence the most common of chronic liver disease in the United States, hepatitis C. Claire Weinberg shares her fight against breast cancer and her involvement as one of the first patients to participate in an IGSP genomic clinical trial. Philip Benfey answers questions regarding a new collaborative agreement between GrassRoots Biotechnology Inc. and Monsanto. Finally, IGSP is leading efforts to predict common infectious illnesses even before symptoms strike. 