Computational Biology & Bioinformatics

PHD in Computational Biology & Bioinformatics

Program Principles & Goals

The PhD Program in Computational Biology & Bioinformatics (CBB) is an integrative, multi-disciplinary training program that encompasses the study of biology using computational and quantitative methods. In and out of the classroom, students learn to apply the tools of statistics, mathematics, computer science and informatics to biological problems. The vibrant and innovative Duke research in these fields provides exciting interactions between biological and computational scientists. Because the Program in Computational Biology and Bioinformatics is based in the Duke Center for Genomic and Computational Biology, it offers a unique opportunity for students to become one of tomorrow's leaders in the genome sciences.

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  • Greg Crawford, PhD
    Associate Professor in Pediatrics
    My research involves identifying gene regulatory elements across the genome to help us understand how chromatin structure dictates cell function and fate. For the last 30 years, mapping DNase I hypersensitive sites has been the gold standard method to identify the location of active regulatory elements, including promoters, enhancers, silencers, and locus control regions. I have developed technologies that can identify most DNase I hypersensitive sites from potentially any cell type from any species with a sequenced genome. We are combining this data with other wet-lab and computational data types to better understand how these regulatory regions control global gene expression in a set of diverse tissues (normal and diseased) representative of the human body.
    Research Interests
    • Gene Regulatory Elements
    • Chromatin Structure
    • Epigenomic Analysis
    • DNase-seq

Ian McDowell

3rd year CBB Student Tim Reddy Lab
Nov 30
Sayan Mukherjee
Duke University, Department of Statistical Science

Nonlinear mixed models for statistical genetics and pedigree analysis from low coverage sequencing data

Dec 1
Andrea L. Meredith, PhD, Associate Professor of Physiology, University of Maryland
Duke Neurobiology

Neurobiology Invited Seminar Series

Dec 1
Jef Boeke
NYU Langone Medical Center

Synthesizing chromsomes from scratch