Phosphorylation of MeCP2 at Ser421 Contributes to Chronic Antidepressant Action.
Hutchinson AN, Deng JV, Cohen S, West AE, J Neurosci. 2012 Oct 10;32(41):14355-63. Abstract
IGSP Faculty
Anne E. West, MD, PhDAnne E. West, MD, PhD
Assistant Professor, Department of Neurobiology
My lab studies the mechanisms and consequences of regulated transcription in neurons. One of our areas of study is how chromatin regulatory proteins mediate adaptations in neuronal gene expression programs during brain development and neuronal plasticity. We are particularly interested in identifying ways in which disruption of chromatin regulation may underlie the development of neuropsychiatric disorders.
Recent Publications
Members of the myocyte enhancer factor 2 transcription factor family differentially regulate BDNF transcription in response to neuronal depolarization.
Lyons MR, Schwarz CM, West AE, J Neurosci. 2012 Sep 12;32(37):12780-5. Abstract
Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes.
Su D, Cha YM, West AE, Epigenetics. 2012 Feb;7(2):146-54. Abstract
Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.
West AE, Neuron. 2012 Jan 12;73(1):1-3. Abstract
Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function.
Cohen S, Gabel HW, Hemberg M, Hutchinson AN, Sadacca LA, Ebert DH, Harmin DA, Greenberg RS, Verdine VK, Zhou Z, Wetsel WC, West AE, Greenberg ME, Neuron. 2011 Oct 6;72(1):72-85. Abstract
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